Table 2.
Comparison between different inherited epidermolysis bullosa types and healthy controls.
| Parameter | Total EB Cases n = 42 | Other EB Types n = 23 | RDEB n = 19 | p-Value | Corrected p-Value* | Controls n = 38 | p-Value | Corrected p-Value * |
|---|---|---|---|---|---|---|---|---|
| Anti-skin antibodies, U/mL | ||||||||
| DSG1 | 3.83 (0.18–38.83) | 2.67 (0.18–20.2) | 5.62 (1.25–38.83) | 0.022 | 0.066 | 2.12 (0–15.09) | 0.331 | 0.382 |
| DSG3 | 3.72 (0–40.4) | 2.8 (0–10.02) | 6.14 (0.94–40.4) | <0.001 | <0.001 | 1.58 (0.08–8.38) | 0.101 | 0.152 |
| BP180 | 7.1 (0.5–118.8) | 5.7 (0.5–83.3) | 14.2 (2.2–118.8) | 0.005 | 0.019 | 1.82 (0–34.41) | 0.015 | 0.038 |
| BP230 | 4.75 (0.5–66) | 3.7 (0.5–15.6) | 12.7 (1.97–66) | 0.003 | 0.015 | 1.68 (0.22–26.74) | 0.02 | 0.043 |
| COL7 | 1.92 (0–41.05) | 1.08 (0–7.58) | 4.96 (0.3–41.05) | <0.001 | <0.001 | 0.26 (0–3.99) | <0.001 | <0.001 |
| Cytokines, pg/mL | ||||||||
| IL-1β | 16.62 (1.16–192.67) | 8.03 (1.16–144.31) | 37.74 (2.23–192.67) | 0.101 | 0.216 | 2.75 (0.88–189.66) | 0.009 | 0.027 |
| IL-2 | 111.23 (18.76–3992.66) | 105.15 (18.76–3992.66) | 120.7 (34.86–3475.02) | 0.548 | 0.685 | 31.61 (8.01–2400) | 0.002 | 0.008 |
| IL-4 | 0.96 (0.79–4.5) | 0.96 (0.79–4.5) | 0.96 (0.79–3.26) | 0.39 | 0.65 | 0.94 (0.6–2.07) | 0.153 | 0.202 |
| IL-6 | 33.44 (5.32–1000) | 23.77 (5.32–1000) | 40.37 (9.28–858.09) | 0.086 | 0.215 | 8.54 (4.46–1000) | 0.002 | 0.008 |
| IL-8 | 45.09 (13.14–449) | 44 (13.14–449) | 49.7 (21.97–124.24) | 0.617 | 0.712 | 27.96 (12.96–939.06) | 0.471 | 0.505 |
| IL-10 | 32.98 (8–250) | 42.59 (8–250) | 30.95 (12.96–187.6) | 0.969 | 0.969 | 21.12 (5.86–250) | 0.034 | 0.06 |
| IL-12 | 1.52 (1.14–9.21) | 1.44 (1.14–9.21) | 1.65 (1.22–3.8) | 0.493 | 0.672 | 1.36 (1–7.29) | 0.162 | 0.202 |
| TNF-α | 175.12 (137.66–4800) | 165.29 (137.66–1364.65) | 176.27 (148.9–4800) | 0.363 | 0.65 | 176.1 (128.17–1351.09) | 0.648 | 0.648 |
| TNF-β | 1737.07 (1101.8–36,000) | 1753.29 (1101.8–36,000) | 1719.14 (1149.51–36,000) | 0.75 | 0.804 | 1267.11 (802.84–3764.79) | <0.001 | <0.001 |
| IFN-γ | 330.16 (79.18–5000) | 279.12 (79.18–5000) | 360.25 (110.6–4607.18) | 0.468 | 0.672 | 176.34 (73.56–4910) | 0.036 | 0.06 |
BP180: antibodies against bullous pemphigoid 180; BP230: antibodies against bullous pemphigoid 230; COL7: type VII collagen; DEB: dystrophic epidermolysis bullosa; DSG1: antibodies against desmoglein 1; DSG3: antibodies against desmoglein 3; EB: inherited epidermolysis bullosa; IFN: interferon; IL: interleukin; RDEB: recessive dystrophic inherited epidermolysis bullosa; TNF: tumor necrosis factor. Median values (range in parentheses). * p-Values were adjusted for multiple testing using the false discovery rate method (with the Benjamini-Hochberg procedure). Controls were compared with other EB types.