Table 3.
Comparison between generalized and localized inherited epidermolysis bullosa types and healthy controls.
| Parameter | Total EB Cases n = 42 | Localized EB n = 18 | Generalized EB n = 24 | p-Value | Corrected p-Value* | Controls n = 38 | p-Value | Corrected p-Value * |
|---|---|---|---|---|---|---|---|---|
| Anti-skin antibodies, U/mL | ||||||||
| DSG1 | 3.83 (0.18–38.83) | 2.33 (0.18–20.2) | 5.54 (1.1–38.83) | 0.016 | 0.048 | 2.12 (0–15.09) | 0.629 | 0.629 |
| DSG3 | 3.72 (0–40.4) | 2.56 (0–35.13) | 5.19 (0.94–40.4) | 0.007 | 0.026 | 1.58 (0.08–8.38) | 0.266 | 0.348 |
| BP180 | 7.1 (0.5–118.8) | 3.65 (0.–26.3) | 13.37 (2.4–118.8) | 0.001 | 0.005 | 1.82 (0–34.41) | 0.073 | 0.137 |
| BP230 | 4.75 (0.5–66) | 3 (0.5–15.6) | 8.1 (1.9–66) | <0.001 | <0.001 | 1.68 (0.22–26.74) | 0.122 | 0.183 |
| COL VII | 1.92 (0–41.05) | 0.96 (0–8.2) | 4.92 (0.51–41.05) | <0.001 | <0.001 | 0.26 (0–3.99) | 0.01 | 0.036 |
| Cytokines, pg/mL | ||||||||
| IL-1β | 16.62 (1.16–192.67) | 10.49 (1.16–180.69) | 21.07 (1.43–192.67) | 0.332 | 0.553 | 2.75 (0.88–189.66) | 0.019 | 0.048 |
| IL-2 | 111.23 (18.76–3992.66) | 87.12 (18.76–3992.66) | 116.53 (24.76–3475.02) | 0.792 | 0.927 | 31.61 (8.01–2400) | 0.004 | 0.03 |
| IL-4 | 0.96 (0.79–4.5) | 0.99 (0.79–4.5) | 0.96 (0.79–3.26) | 0.729 | 0.927 | 0.94 (0.6–2.07) | 0.278 | 0.348 |
| IL-6 | 33.44 (5.32–1000) | 14.98 (5.32–1000) | 39.44 (9.73–858.09) | 0.091 | 0.227 | 8.54 (4.46–1000) | 0.012 | 0.036 |
| IL-8 | 45.09 (13.14–449) | 42.9 (13.14–449) | 51.44 (13.61–124.24) | 0.307 | 0.553 | 27.96 (12.96–939.06) | 0.426 | 0.467 |
| IL-10 | 32.98 (8–250) | 66.29 (8–250) | 32.17 (12.96–187.6) | 0.865 | 0.927 | 21.12 (5.86–250) | 0.102 | 0.17 |
| IL-12 | 1.52 (1.14–9.21) | 1.73 (1.14–9.21) | 1.44 (1.16–7.14) | 0.165 | 0.354 | 1.36 (1–7.29) | 0.026 | 0.056 |
| TNF-α | 175.12 (137.66–4800) | 167.75 (145.89–1364.65) | 184.22 (137.66–4800) | 0.816 | 0.927 | 176.1 (128.17–1351.09) | 0.436 | 0.467 |
| TNF-β | 1737.07 (1101.8–36,000) | 1719.99 (1101.8–36,000) | 1753.29 (1149.51–36,000) | 1 | 1 | 1267.11 (802.84–3764.79) | <0.001 | <0.001 |
| IFN-γ | 330.16 (79.18–5000) | 357.05 (79.18–5000) | 330.16 (110.6–4607.18) | 0.85 | 0.927 | 176.34 (73.56–4910) | 0.011 | 0.036 |
BP180: antibodies against bullous pemphigoid 180; BP230: antibodies against bullous pemphigoid 230; COL7: type VII collagen; DSG1: antibodies against desmoglein 1; DSG3: antibodies against desmoglein 3; EB: inherited epidermolysis bullosa; IFN: interferon; IL: interleukin; TNF: tumor necrosis factor. Median values (range in parentheses). * p-Values were adjusted for multiple testing using the false discovery rate method (with the Benjamini-Hochberg procedure). Controls were compared with localized EB.