Table 5.
Correlation between anti-skin antibodies, serum cytokine levels, and the Birmingham Epidermolysis Bullosa Severity (BEBS) score in inherited epidermolysis bullosa patients.
| Parameter | Spearman p | p-Value | Corrected p-Value * |
|---|---|---|---|
| Anti-skin antibodies, U/mL | |||
| DSG1 | 0.32 | 0.039 | 0.084 |
| DSG3 | 0.331 | 0.032 | 0.08 |
| BP180 | 0.449 | 0.003 | 0.015 |
| BP230 | 0.507 | 0.001 | 0.008 |
| COL VII | 0.588 | <0.001 | <0.001 |
| Cytokines, pg/mL | |||
| IL-1β | 0.208 | 0.187 | 0.351 |
| IL-2 | 0.064 | 0.688 | 0.794 |
| IL-4 | −0.156 | 0.331 | 0.485 |
| IL-6 | 0.401 | 0.008 | 0.03 |
| IL-8 | −0.127 | 0.43 | 0.636 |
| IL-10 | 0.135 | 0.402 | 0.548 |
| IL-12 | −0.378 | 0.018 | 0.054 |
| TNF-α | 0.145 | 0.359 | 0.538 |
| TNF-β | −0.015 | 0.926 | 0.926 |
| IFN-γ | −0.026 | 0.868 | 0.926 |
BP180: antibodies against bullous pemphigoid 180; BP230: antibodies against bullous pemphigoid 230; COL7: type VII collagen; DSG1: antibodies against desmoglein 1; DSG3: antibodies against desmoglein 3; EB: inherited epidermolysis bullosa; IFN: interferon; IL: interleukin; TNF: tumor necrosis factor. Median values (range in parentheses). * p-Values were adjusted for multiple testing using the false discovery rate method (with the Benjamini-Hochberg procedure).