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. 2016 Sep 29;17(10):1636. doi: 10.3390/ijms17101636

Figure 2.

Figure 2

Bidirectional transport of AAs regulates mTORC1 activity. ASCT2 transports glutamine into the cell to increase its intracellular concentration. LAT1-4F2hc is a bidirectional transporter that mediates the simultaneous efflux of glutamine out of cells and uptake of extracellular leucine, which in turn activates mTORC1 signaling. AAs: amino acids; mTORC1: mammalian target of rapamycin complex 1; ASCT2: system ASC AA transporter 2; LAT1: system L amino acid transporter 1; 4F2hc: heavy chain of 4F2 cell surface antigen.