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. 2016 Sep 27;17(10):1638. doi: 10.3390/ijms17101638

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic summary of homeodomain-interacting protein kinase 2 (HIPK2) structure. The N-terminal domain contains the sumoylation sites (K25). D916 and D977 are caspase-6 cleavage sites. K1182 is the ubiquitylation site. Some HIPK2-interacting proteins are shown. SUMO, sumoylation; Ub, ubiquitylation; HID, homeobox-interacting domain; SRS, speckle-retention signal; AID, auto-inhibitory domain; MeCP, methyl-CpG-binding protein 2; CtBP, C-terminal binding protein; CBP, cAMP-response element-binding protein (CREB)-binding protein; ZBTB4, zinc-finger and BTB domain containing 4.