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. 2016 Sep 28;17(10):1648. doi: 10.3390/ijms17101648

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of quinidine and quinine on the pentamidine- or desipramine-induced hERG defect. (A) Different concentrations of quinidine (1, 10, and 30 μM) did not upregulate the expression of 155-kDa hERG after 30 μM pentamidine treatment. * p < 0.05 vs. control, n = 3; (B) Different concentrations of quinine (1, 10, and 30 μM) did not upregulate the expression of 155-kDa hERG after 30 μM pentamidine treatment. * p < 0.05 vs. control, n = 3; (C) Different concentrations of quinidine (1, 10, and 30 μM) did not upregulate the expression of 155-kDa hERG after 30 μM desipramine treatment. * p < 0.05 vs. control, n = 3; (D) Different concentrations of quinine (1, 10, and 30 μM) did not upregulate the expression of 155-kDa hERG after 30 μM desipramine treatment. * p < 0.05 vs. control, n = 3. The hERG-HEK cells were incubated with the drugs for 24 h. Abbreviation: ctl, control.

Effects of quinidine and quinine on the pentamidine- or desipramine-induced hERG defect. (A) Different concentrations of quinidine (1, 10, and 30 μM) did not upregulate the expression of 155-kDa hERG after 30 μM pentamidine treatment. * p < 0.05 vs. control, n = 3; (B) Different concentrations of quinine (1, 10, and 30 μM) did not upregulate the expression of 155-kDa hERG after 30 μM pentamidine treatment. * p < 0.05 vs. control, n = 3; (C) Different concentrations of quinidine (1, 10, and 30 μM) did not upregulate the expression of 155-kDa hERG after 30 μM desipramine treatment. * p < 0.05 vs. control, n = 3; (D) Different concentrations of quinine (1, 10, and 30 μM) did not upregulate the expression of 155-kDa hERG after 30 μM desipramine treatment. * p < 0.05 vs. control, n = 3. The hERG-HEK cells were incubated with the drugs for 24 h. Abbreviation: ctl, control.