Table 3.
Studies of platelets and platelet-derived factors: effects on inflammatory processes in transgenic mice.
| Mouse Line (Genetic Background) | Model (Peptide) | Inflammatory Effect | Reference |
|---|---|---|---|
| Cox1−/− | K/BxN serum transfer arthritis (K/BxN serum) | Ameliorated disease course due to platelet-derived COX-1 | [53] |
| Gp1ba−/− (C57BL/6) | K/BxN serum transfer arthritis (K/BxN serum) | No clinical effect | [70] |
| Gp6−/− (C57BL/6) | K/BxN serum transfer arthritis (K/BxN serum) | Decreased disease severity. Reduced inflammation, bone erosion, cartilage erosion | [70] |
| Tbxas1−/− (C57BL/6) | K/BxN serum transfer arthritis (K/BxN serum) | No effect on clinical symptoms | [70] |
| CD40−/− (C57BL/6) | Colitis (DSS) | Attenuated disease activity, reduced inflammation and MPO activity, reduced platelet and leukocyte adhesion | [81] |
| CD40L−/− (C57BL/6) | Colitis (DSS) | Attenuated disease activity, reduced inflammation and MPO activity, reduced platelet and leukocyte adhesion | [81] |
| P-Selectin−/− (C57BL/6) | Colitis (DSS) | Reduced platelet adhesion and rolling | [81] |
| Reduced platelet adhesion, decreased albumin extravasation | [82] | ||
| Enhanced disease activity, reduced MPO activity, inflammation, leukocyte rolling | [83] | ||
| PSGL-1−/− (C57BL/6) | Colitis (DSS) | Reduced platelet adhesion and rolling | [81] |
| Earlier disease onset, enhanced disease activity, enhanced infiltration, platelets not examined | [84] | ||
| Decreased disease activity, inflammation, reduced Th1 and Th17 infiltration, platelets not examined | [85] | ||
| PSGL-1−/− (Balb/c) | Colitis (DSS) | Reduced clinical disease activity, decreased leukocyte rolling, inflammation and MPO activity, platelets not examined | [86] |
Abbreviations: Cox1, cyclooxygenase-1; DSS, dextran sulfate sodium ; Gp, glycoprotein; K/BxN, KRN and MHC class II molecule I-A (g7); MPO, myeloperoxidase; Tbxas1, Thromboxane A synthase 1.