Table 3.

Histological evaluation on contra-lateral healthy and ischemic kidney of control and OHR rats.

Rat Groups	Healthy vs. Ischemic	Mesangial Hypercellularity	Mesangial Matrix Expansion	Focal/Segment Glomerulo-Sclerosis	Tubular Casts	Tubular Damage	Interstitial Inflammation	Interstitial Fibrosis
Control	healthy	+	+	2/30	+/−	+	+	+
	ischemic	++	+	6/30	++	++	++	++
Control + R	healthy	++	++	4/30	+	+	+	+
	ischemic	++	++	6/30	+	+	++	+
OHR	healthy	+	++	4/30	+	+	+	++
	ischemic	+	+	5/30	+++	+++	+++	++
OHR+R	healthy	++	+	5/30	−	+	+	+
	ischemic	+	+	6/30	+	+	+	+

Histological evaluation was performed on two rats per each group and was scored semi-quantitatively from − to +++ (−, none; +, mild; ++, moderate; +++, severe). Glomerular evaluation was performed on 30 glomeruli per section and the presence of segmental and global glomerulosclerosis was quantified. Representative histological images are shown in Figure 5. R = Rostafuroxin.