Figure 4.

(a–c): The concentration dependency of [¹⁴C]fluciclovine in (a) P-glycoprotein (P-gp)-; (b) breast cancer resistance protein (BCRP)-; and (c) multidrug resistance-associated protein 4 (MRP4)-expressing inside-out vesicles; (d–f): the inhibition of tracer uptake by unlabeled fluciclovine in (d) P-gp-; (e) BCRP-; and (f) MRP4-expressing inside-out vesicles. Each data point represents the mean ± SD (n = 3–6). “ES” and “E2G” indicate “[³H]estrone-3-sulfate” and “[³H]estradiol-17β-d-glucuronide”, respectively.