Figure 2.

Schematic depiction of a system in which individual monomers lack hydrophobic cores but the dimer as a whole contains a well-defined core. Elimination of residues involved in complexation distorts the dimeric core while bolstering the monomeric cores—The black frame (right-hand schema) symbolizes the interface, which has been eliminated from RD calculation to characterize its influence on the status of the dimer, as well as the status of each monomer. Blue and pink lines: distributions in monomers, gray line: distribution in dimer. (A) Status of the individual monomers (blue and pink) versus the resultant distribution in dimer (gray); (B) the removal of the interface (black bar) does not change the status of the dimer—Distribution accordant versus the expected one.