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. Author manuscript; available in PMC: 2017 Nov 6.
Published in final edited form as: J Mol Biol. 2016 Sep 23;428(22):4503–4519. doi: 10.1016/j.jmb.2016.09.016

Figure 7. Mutations associated with daptomycin resistance are located within the receiver domain.

Figure 7

(a) Expanded view of the Efm LiaR receiver domains showing the positions of the mutations W73C and S19F. The S19F mutation (yellow/cyan sticks) is within the dimerization interface, while the adaptive mutation W73C (yellow/cyan sticks) is not located within the molecular surfaces that comprise the LiaR dimer: (b) Structural alignment of the activated Efm LiaR receiver (blue) compared to the inactive state structures of VraR/NarL receiver domains (cyan/light pink). Position 73 in the VraR and NarL structures are depicted as sticks (cyan/light pink, respectively).