Table 2.
Discharge / Day 7 Characteristics by Trial
| Characteristic | Overall (N=744) | DOSE (N=260) | CARRESS (N=147) | ROSE (N=337) |
|---|---|---|---|---|
| Days from randomization to discharge | 6 (4 - 9) | 5 (3 - 9) | 7 (5 - 11) | 6 (4 - 9) |
| Edema ≥ 2 | 168/710 (23.7) | 55/245 (22.4) | 48/141 (34.0) | 65/324 (20.1) |
| JVP ≥ 8 cm water | 330/636 (51.9) | 100/213 (46.9) | 81/128 (63.3) | 149/295 (50.5) |
| Heart rate | 72.5 (65.0 - 83.0) | 75.0 (66.0 - 85.5) | 73 (65 - 83) | 72 (64 - 81) |
| SBP, mmHg | 110 (100 - 125) | 110 (100 - 125) | 117 (102 - 128) | 107 (98 - 124) |
| DBP, mmHg | 61 (56 - 70) | 63.5 (56.0 - 72.0) | 62 (56 - 71) | 60 (55 - 67) |
| Weight, lbs | 190 (162 - 240) | 189 (163 - 232) | 203 (168 - 261) | 187 (159 - 233) |
| Weight change, lbs | −10.5 (−17.4, −5.51) | −10.6 (−15.9, −5.51) | −15.0 (−21.8, −7.90) | −9.26 (−15.4, −4.85) |
| BMI, kg/m2 | 29.5 (24.8 - 36.1) | 29.1 (24.6 - 35.2) | 30.7 (25.8 - 38.4) | 29.1 (24.3 - 36.0) |
| Orthopnea | 417/631 (66.1) | 132/205 (64.4) | 87/129 (67.4) | 198/297 (66.7) |
| Orthoedema score | ||||
| 0 | 405/713 (56.8) | 147/247 (59.5) | 69/142 (48.6) | 189/324 (58.3) |
| 1 | 70/713 (9.8) | 26/247 (10.5) | 20/142 (14.1) | 24/324 (7.4) |
| 2 | 148/713 (20.8) | 46/247 (18.6) | 27/142 (19.0) | 75/324 (23.1) |
| 3 | 63/713 (8.8) | 24/247 (9.7) | 18/142 (12.7) | 21/324 (6.5) |
| 4 | 27/713 (3.8) | 4/247 (1.6) | 8/142 (5.6) | 15/324 (4.6) |
| Medications | ||||
| ACEI/ARB | 334/682 (49.0) | 164 (63.1) | 56 (38.1) | 114/275 (41.5) |
| Hydralazine | 146/682 (21.4) | 54 (20.8) | 32 (21.8) | 60/275 (21.8) |
| Nitrates | 215/682 (31.5) | 86 (33.1) | 55 (37.4) | 74/275 (26.9) |
| Beta blocker | 549/682 (80.5) | 205 (78.8) | 122 (83.0) | 222/275 (80.7) |
| Aldosterone antagonist | 218/682 (32.0) | 96 (36.9) | 33 (22.4) | 89/275 (32.4) |
| Digoxin | 189/682 (27.7) | 93 (35.8) | 28 (19.0) | 68/275 (24.7) |
| Aspirin | 491/682 (72.0) | 188 (72.3) | 110 (74.8) | 193/275 (70.2) |
| Warfarin | 302/682 (44.3) | 127 (48.8) | 61 (41.5) | 114/275 (41.5) |
| Local Labs | ||||
| Sodium, mEq/L | 137 (135 - 140) | 137 (135 - 140) | 137 (133 - 139) | 137 (135 - 140) |
| Potassiumm, mEq/L | 4.0 (3.8 - 4.4) | 4.0 (3.7 - 4.3) | 4.2 (3.9 - 4.5) | 4.0 (3.7 - 4.3) |
| BUN, mg/dL | 44 (30 - 63) | 36 (25 - 53) | 60.0 (39.2 - 79.0) | 44.0 (31.0 - 58.4) |
| Bicarbonate, mEq/L | 29 (27 - 32) | 29 (27 - 32) | 29 (26 - 33) | 29 (27 - 32) |
| Creatinine, mg/dL | 1.72 (1.38 - 2.17) | 1.60 (1.20 - 2.00) | 2.00 (1.58 - 2.60) | 1.70 (1.40 - 2.13) |
| eGFR, mg/dL | 40.6 (31.4 - 53.7) | 45.3 (34.1 - 65.2) | 35.0 (25.1 - 44.3) | 40.0 (31.8 - 51.8) |
| SpO2, % | 96 (95 - 98) | 97 (95 - 98) | - | 96 (95 - 98) |