Table 3.

ASCs cytokine profile

Function	Secreted protein
Immunomodulation	TGF-β, HGF, PGE2, IL-6
Vascularization	VEGF, HGF, TGF-β2, FGF-2, bFGF, GM-CSF
CUN regeneration	BDNF, NGF, GDNF, IGF-1
Hematopoiesis suport	HGF, GM-CSF, IL-6,7,8,11, TNF-α
Other	Adiponectin, angiotensin, cathepsin D, retinol binding protein, CXCL12

Modified according to Salgado et al. (2010)

Adipose-derived stem cells secrete several cytokines and growth factors that modulate immune response and facilitate regeneration of damaged tissues. These soluble mediators exhibit positive effect on central nervous system, heart, muscles and even the general vitality of cells

GM-CSF granulocyte/macrophage colony-stimulating factor, TGF-β transforming growth factor β, FGF-2 fibroblast growth factor 2, BDNF brain derived neurotrophic factor, GDNF glial derived neurotrophic factor, NGF nerve growth factor