Table 1.
Effects of lifestyle intervention on prevention of diabetes in three landmark studies [39, 40••, 41–44]
| Trials | Subjects with prediabetes (IGT or IFG) | Follow-up period | Incidence of diabetes (intervention versus control) | Extended follow-up period | Incidence of diabetes (intervention versus control) | |
|---|---|---|---|---|---|---|
| Lifestyle intervention | Control | HR(95 % CI) | HR(95 % CI) | |||
| Da Qing Study | 439 | 138 | 6 years | 0.49(0.33–0.73) | 23 years | 0.55(0.40–0.76) |
| Finnish Diabetes Prevention Study | 265 | 257 | 3.2 years | 0.42(0.30–0.70) | 13 years | 0.61(0.48–0.79) |
| Diabetes Prevention Program Study | 1079 | 1082 | 2.8 years | 0.58(0.48–0.66) | 15 years | 0.73(0.65–0.83) |
CI confidence interval; HR hazard ratio; IGT/IFG impaired glucose tolerance/impaired fasting glycemia