Table 2.

Genotype frequencies in men group according to cases and controls

Polymorphism		Cases A		Cases B		Controlsa		ORb	CI 95 %		Cases vs. controls
		N	%	N	%	N	%
HLA-G 14 bp ins/del	del/del	29	36.7	61	30.8	75	34.2	1			χ 2df=4 = 1.57 p = 0.8136
	del/ins	30	38	81	40.9	91	41.6	1.02	0.67	1.53
	ins/ins	20	25.3	56	28.3	53	24.2	1.19	0.75	1.90
	∑	79	100	198	100	219	100
	H-W	p = 0.0418		p = 0.0107		p = 0.02
	f	0.23		0.18		0.16
HLA-G −725	CC	43	54.5	142	71.7	145	66.2	1			χ 2df=6 = 11.1 p = 0.1959
	CG	31	39.2	46	23.3	55	25.1	1.10	0.73	1.65
	CT	3	3.8	6	3	12	5.5	0.60	0.25	1.42
	GG	2	2.5	3	1.5	5	2.3	0.78	0.24	2.61
	GT	0	0	1	0.5	2	0.9	0.47	–	–
	∑	79	100	198	100	219	100
	H-W	p = 0.5701		p = 0.9154		p = 0.9989
	f	–0.09		–0.008		0.008
HLA-G −716	TT	28	35.4	42	21.2	52	23.7	1			χ 2df=4 = 7.76 p = 0.1008
	GT	27	34.2	95	48	105	47.9	0.86	0.56	1.35
	GG	24	30.4	61	30.8	62	28.3	1.02	0.63	1.65
	∑	79	100	198	100	219	100
	H-W	p = 0.0064		p = 0.6681		p = 0.5885
	f	0.314		0.031		0.039
KIR2DL4 9620	9A/9A	22	27.8	59	29.8	74	33.8	1			χ 2df=4 = 4.12 p = 0.3904
	9A/10A	42	53.2	103	52	95	43.4	1.39	0.93	2.09
	10A/10A	15	19	36	18.2	50	22.8	0.93	0.57	1.54
	∑	79	100	198	100	219	100
	H-W	p = 0.651		p = 0.4747		p = 0.0756
	f	–0.072		–0.055		0.122
KIR2DL4 9571	TT	22	27.8	59	29.8	78	35.6	1			χ 2 = 4.1 p = 0.3921
	CT	42	53.2	103	52	95	43.4	1.47	0.98	2.20
	CC	15	19	36	18.2	46	21	1.07	0.64	1.76
	∑	79	100	198	100	219	100
	H-W	p = 0.651		p = 0.4747		p = 0.0979
	f	–0.072		–0.055		0.113
KIR2DL4 9769	CC	53	67.1	144	72.7	170	77.6	1			χ 2df=4 = 4.07 p = 0.4033
	CA	23	29.1	45	22.7	42	19.2	1.39	0.90	2.15
	AA	3	3.8	9	4.6	7	3.2	1.44	0.57	3.64
	∑	79	100	198	100	219	100
	H-W	p = 0.7153		p = 0.0568		p = 0.0597
	f	0.028		0.15		0.14
KIR2DL4 9797	GG	22	27.8	56	28.3	77	35.2	1			χ 2df=4 = 4.6 p = 0.3304
	GA	42	53.2	107	54	97	44.3	1.51	1.01	2.27
	AA	15	19	35	17.7	45	20.5	1.10	0.66	1.82
	∑	79	100	198	100	219	100
	H-W	p = 0.651		p = 0.2495		p = 0.168
	f	–0.072		–0.093		0.095
LILRB1 5651	GG	66	83.5	162	81.8	190	86.7	1			χ 2df=4 = 2.24 p = 0.6987
	GA	10	12.7	28	14.1	24	11	1.31	0.76	2.25
	AA	3	3.8	8	4.1	5	2.3	1.74	0.62	4.90
	∑	79	100	198	100	219	100
	H-W	p = 0.026		p = 0.0006		p = 0.0046
	f	0.3		0.28		0.235

Cases A patients with two miscarriages; Cases B patients with three or more miscarriages, N number of cases, P probability, OR odds ratio, 95 % CI confidence interval, H-W Hardy–Weinberg equilibrium, f < 0 correspond to deficiency of homozygotes, f > 0 correspond to excess of homozygotes, f = 0 in case of H-W

^a Frequencies of KIR2DL4 polymorphisms in Controls were described previously by Nowak et al. (2015). ^b Odds ratio computed for [cases A plus cases B] vs. controls