Fig. 6.

The expression of RhoA is attenuated in C/EBPδ-positive astrocytes along the glial limitans in the immediate vicinity of the lesion epicenter 14 days after SCI. Immunostaining demonstrates a regional heterogeneity in the expression of C/EBPδ and RhoA in injured wild-type mice. GFAP-positive astrocytes boarding the lesion epicenter (dotted line) show increased C/EBPδ but reduced RhoA expression, whereas those at the penumbral region between the lesion border and the less injured tissue exhibit converse results. In the C/EBPδ ^−/− mice, RhoA is expressed in astrocytes ubiquitously in the injured spinal cord. The boxed area is enlarged in the upper right corner of each photograph