Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Oct 28;4:113. doi: 10.1186/s40478-016-0383-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 3 — Presence of UPR activation markers and GVD in the frontal cortex of an unusual GSS case carrying a PRNP Q227X mutation (case #14). a Immunohistochemical detection of PrP using the 3F4 antibody in the frontal cortex. b Detection of hyperphosphorylated tau (AT8 antibody) in the frontal cortex. c Localization of pPERK in GVD structures (see inset) in the frontal cortex. d Immunohistochemical detection of CK1δ shows staining of GVD structures in the frontal cortex. e Immunohistochemical staining for pIRE1α shows absence of pIRE1α immunoreactivity. f Immunohistochemical detection of PrP using the 3F4 antibody in the frontal cortex shows intraneuronal detection in granular structures resembling GVD. Insets show higher magnification of indicated area. a-f Brown staining with DAB, blue staining of the nucleus with haematoxylin. Bar a, b 100 μm; c-f 20 μm