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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: Curr Biol. 2016 Jul 11;26(13):R628–R639. doi: 10.1016/j.cub.2016.05.025

Figure 2. Major pathways that underlie axonal pruning and dying back neurodegeneration.

Figure 2

Illustration of the main pathways that control developmental axon pruning and axon degeneration by dying back, see text for details. Blue, red and purple text – genes and pathways involved in dying back neurodegeneration (blue), developmental neuronal remodeling (red) or both (purple). MT-Microtubules, Ub-Ubiquitin, UPS-Ubiquitin Proteasome System, TGFβ - Transforming growth factor-β, ESCRT -The endosomal sorting complexes required for transport, Caspases - cysteine-aspartic proteases or cysteine-dependent aspartate-directed proteases.