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. Author manuscript; available in PMC: 2017 Apr 10.
Published in final edited form as: Nat Genet. 2016 Oct 10;48(11):1425–1429. doi: 10.1038/ng.3675

Figure 2. KEGG Pathway for IgA Production Associated with IgAD.

Figure 2

A GWAS-based pathway analysis of IgAD meta-analysis P-values was performed of all 221 KEGG database pathways using PARIS and INRICH software (see Methods). A top identified pathway (P < 0.0001 based on 10,000 permutations) was the “Intestinal Immune Network for IgA Production” where 22/30 annotated pathway genes contained variants with a P value < 0.05 in the IgAD meta-analysis. The colors of the boxes around the gene names correspond to the smallest P value observed in the IgAD meta-analysis within that gene: blue, P < 1x10−5; green, 1x10−5< P < 1x10−3; yellow, 1x10−3< P < 0.01; red, 0.01 < P < 0.05, white P ≥ 0.05.

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