Table 1. Case-Control Cohorts for IgAD GWAS.
| Cohortsa | Cases (N) | Controls (N) | Total (N) | Significant Ancestry Eigenvectors (N) | Genomic Inflation Factor (λGC)b | SNPs Genotyped (N) | SNPs after Imputation (N) | Median Info Score |
|---|---|---|---|---|---|---|---|---|
| Meta | 1,635 | 4,852 | 6,487 | 556,344a | 9,464,381 | |||
|
| ||||||||
| 2016 (New) | ||||||||
| Swedish | 483 | 1,932 | 2,415 | 2 | 1.03 | 423,694 | 9,464,381 | 0.988 |
| Spanish | 150 | 230 | 380 | 0 | 1.04 | 339,552 | 8,534,763 | 0.974 |
| Italian | 91 | 364 | 455 | 4 | 1.03 | 218,770 | 8,365,602 | 0.948 |
| Czech | 151 | 602 | 753 | 4 | 1.05 | 112,822 | 6,282,267 | 0.929 |
|
| ||||||||
| 2010 | ||||||||
| Swedish | 421 | 1,080 | 1,501 | 5 | 1.03 | 289,843 | 8,765,152 | 0.979 |
| Finnish | 86 | 344 | 430 | 3 | 1.01 | 314,756 | 8,723,593 | 0.984 |
| Spanish | 253 | 300 | 553 | 3 | 1.00 | 538,800 | 8,794,151 | 0.985 |
a
Variants genotyped in >1 cohort.
b
The genomic inflation factor listed is calculated from genotyped variants. However, genomic inflation factors for each cohort were also estimated for imputed SNPs separately, and results did not differ (e.g. maximum genomic inflation factor for imputed variants was 1.06).