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. Author manuscript; available in PMC: 2016 Oct 29.
Published in final edited form as: Nature. 2015 Oct 26;527(7579):531–534. doi: 10.1038/nature15767

Figure 3. Comparison of RdRP in quiescent and transcribing states.

Figure 3

a-b, Ribbon models of RdRP in quiescent (a) and transcribing (b) states. The latter contains fragments of RNA template (orange) and nascent mRNA (cyan) inside the active site (box). c-f, Superpositions of RdRP structures in quiescent (colour) and transcribing (grey) states shown in full (c) and as separate domains – N-terminal (d), polymerase (e), and bracelet (f) with Modules A (yellow) and B (magenta) further highlighted on its right panel. g-i, Densities (grey) and models (ribbons and sticks) of nucleic acids in the active site of RdRP. The fragments of the (−)RNA template and the nascent mRNA in the active site are modelled as a poly-G and poly-C, respectively. In (h), a CTP is placed in the NTP-binding site and in (i), the template and mRNA form RNA duplex in the active site of RdRP (surface-rendered model).