Table 2.

The top 20% genes with the best rank in degree, betweenness centrality, and closeness centrality parameters in the enriched proteinprotein interaction (PPI) network of time 24 hours

Geans	Degree	Geans	Betweenness	Geans	Closeness
TP53	35	TP53	0.338181	TP53	0.397906
FN1	16	MMP2	0.171374	MMP2	0.38191
CTNNB1	15	ALB	0.145517	NOTCH1	0.361045
MMP2	15	CTNNB1	0.125341	ALB	0.356808
ALB	14	NOTCH1	0.11946	AR	0.35023
AR	14	SERPINE1	0.100643	CTNNB1	0.347032
NOTCH1	14	AR	0.085536	SERPINE1	0.344671
SHH	13	FN1	0.075905	SMAD2	0.334802
SMAD2	11	SHH	0.069747	FN1	0.333333
SERPINE1	10	SMAD2	0.069443	ACVR1B	0.326882
COL1A1	9	PRKAR2A	0.067309	ACVR2A	0.326882
PRKAR2A	9	HSPA5	0.067049	SHH	0.325482
MAPK1	9	MAP3K5	0.049224	CD9	0.324094
TGFBI	8	PTHLH	0.047677	MAPK1	0.319328
ACVR1B	8	HRAS	0.045799	NCOR1	0.316667
IFNG	8	TGFBI	0.044403	LAMC2	0.31405
TCF4	8	HNF1B	0.040631	VTN	0.312115
ACVR2A	8	CDKN2A	0.039982	FAS	0.310838
FAS	7	NCOR1	0.039374	TCF4	0.310204
BDNF	7	PAX6	0.038418	SOD2	0.308943
CD9	6	CD9	0.038417	CTBP1	0.307692
LAMC2	6	TCF4	0.037912	PAX6	0.306452
CTBP1	6	NR0B1	0.035918	HES1	0.306452
PAX6	6	FAS	0.035234	HSPA5	0.305835
HES1	6	MAPK1	0.031996	IFNG	0.305221
CSF2	6	NEDD4L	0.030261	KDM1A	0.305221
NR0B1	6	SLC9A3R2	0.028821	TGFBI	0.304609
HNF1B	6	IFNG	0.028734	CSF2	0.304609
LRP2	6	CSF2	0.027151	PRKAR2A	0.304
TRAF2	6	ANXA2	0.026874	DECR1	0.303393
RIPK1	6	PROC	0.026277	PPP2R1A	0.302187
NCOR1	5	KDR	0.024832	DECR1	0.303393
VTN	5	CTBP1	0.024626	PPP2R1A	0.302187
SOD2	5	APOB	0.024534	COL1A1	0.30099
HSPA5	5	TRAF2	0.024347	BDNF	0.298625
CDKN2A	5	F3	0.022625	TDGF1	0.295146
HRAS	5	BDNF	0.022597	F7	0.294574
CYP7A1	5	LRP2	0.022317	NR0B1	0.293436
KDR	5	COL2A1	0.022231	HNF1B	0.292308
ID2	5	GSTA1	0.021794	CDKN2A	0.291747
MAP3K5	5	VTN	0.021145	DUSP5	0.290631
CLU	5	ARF6	0.020175	LRP2	0.290076
NEDD4L	5	YWHAB	0.01996	ANXA2	0.289524
FST	5	ACVR1B	0.018667	F3	0.288425
MSTN	5	ACVR2A	0.018667	PTHLH	0.287335
PROC	5	RALA	0.018621	HRAS	0.286792