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. 2016 Apr 16;401(7):925–935. doi: 10.1007/s00423-016-1425-0

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — a Forest plot of sensitivity of all studies. The pooled result is displayed by the vertical line. Horizontal lines indicate the 95 % confidence intervals of each separate study. Size of the square is directly linked to the number of patients included in the study. b Forest plot of sensitivity of subgroup-analysis depending on domain of included patients. The pooled result is displayed by the vertical line. Horizontal lines indicate the 95 % confidence intervals of each separate study. Size of the square is directly linked to the number of patients included in the study. SE sensitivity, CI confidence interval