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Major biological and pathological activities of SEB
| Superantigenicity: proliferation of CD4 T cells following binding with the Vβ motif of TcR and MHC class II molecules on the surface of APCs |
| Induction and release of several cytokines |
| Lethality and shock in experimental animals, including mice, rabbits, piglets, and monkeys |
| Emetic activity |
| Direct or indirect involvement in pathogenesis of severe diseases, including TSS, nonmenstrual TSS, atopic dermatitis, asthma, and chronic rhinitis |
