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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Hear Res. 2016 Aug 21;341:100–108. doi: 10.1016/j.heares.2016.08.003

Figure 3.

Figure 3

The stria vascularis in Alport mice is under metabolic/oxidative stress and overexpresses transcripts encoding ECM molecules. Stria vascularis was isolated from 7 week Alport mice, strain and age-matched wild type mice, and wild type mice exposed to noise (see methods). RNA was analyzed by real time RT-PCR for transcripts encoding endothelin-1, the ECM molecules known to accumulate in the SCBM (laminin α2, laminin α5, and collagen α1(IV), Panel A), or for hypoxia related factors Hif-1α and VEGF or glucose transporter-1 (Glut1) (Panel B), which is up-regulated under conditions of metabolic stress. Asterisks denotes statistically significant differences (P<0.01).