Skip to main content
. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Hear Res. 2016 Aug 21;341:100–108. doi: 10.1016/j.heares.2016.08.003

Figure 5.

Figure 5

Stria marginal cells respond to both ET-1 and hypoxia by up regulating expression of ECM genes, and the response can be blunted by ETAR blockade. Panel A. Differentiated strial marginal cell cultures were stimulated with ET-1 in the presence or absence of sitaxentan. RNA was analyzed for the indicated ECM transcripts. Panel B. Differentiated strial marginal cells were cultured under normoxic or hypoxic conditions (for 24 hours) and RNA analyzed for the indicated transcripts. Asterisks denote statistically significant differences (P<0.05).