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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Hear Res. 2016 Aug 21;341:100–108. doi: 10.1016/j.heares.2016.08.003

Figure 6.

Figure 6

Endothelin A receptor blockade prevents accumulation of ECM in the Alport strial capillary basement membranes. Alport mice were treated with sitaxentan or vehicle from 2 weeks to 7 weeks of age. Mid-modiolar cryosections were immunostained with antibodies against type IV collagen α1 chain (col α1(IV)), laminin α2 chain (Lam α2), or laminin α5 chain (Lam α5). All sections were stained at the same time and microscope settings standardized to the vehicle-treated Alport cochleae. Arrow heads denote strial capillary basement membranes. Note that vessels in the spiral ligament do not show changes in staining intensity upon sitaxentan treatment, and thus serve as a control.