Figure 1. Populations of auto Ag-specific Tregs that can be generated for cell-based therapies in T1D. Auto Ag specific Tregs can be generated by TCR transduction of CD4+ Tregs, TCR/FoxP3-gene transduction of CD4+ T cells, or TCR/FoxP3-gene transduction of PSCs, followed T-cell differentiation driven by Notch ligands.
