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. 2016 Oct 31;2:16076. doi: 10.1038/cddiscovery.2016.76

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Requirement for PIDD cleavage to PIDD-CC for E1A-enhanced cellular sensitivity of mouse cells to etoposide-induced apoptosis. (a) Western blot for expression of Flag-tagged PIDD-S588A (mtPIDD) (M2), actin and E1A (M73) in E1A-positive control (E1A) and E1A+ mtPIDD cells. Full length (PIDD-FL) and PIDD-C are indicated. A nonspecific band is indicated by an asterisk. (b) E1A+ and E1A+ mtPIDD cells were treated with etoposide for 18 h. Cell viability was determined by MTS staining and expressed as % cell death (mean±S.E.M.; n=3, ***P<0.001).