(b).

References	Country	Animal strain	Animal number	Sex	Age	Weight	Experimental groups	Animal number per group	Numbers of animals per box	Treatment control group	Plant species	Native/exotic	Used parts	Isolated	Dose	Popular indication	Wound area	Measurement interval	Wound area calculation	Treatment time
Ghosh et al., 2012 [39]	India	Wistar rats/Swiss albino mice	36	♂	?	150–180 g/20–25 g	6	6	?	Ointment base	Pedilanthus tithymaloides (Euphorbiaceae)	N	L	2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-one, 1, 2-tetradecanediol, and 1-(hydrogen sulfate)	50 mg	Antiviral, antibacterial, antihemorrhagic, antitumor, abortive, and anti-inflammatory activities	500 mm2	3/3 days	(%) wound contraction 1/4 (initial × final wound area) × 100	21 days
Mukherjee et al., 2013 [40]	India	Swiss albino mice/Wistar rats	?	?	?	18–20 g/150–180 g	10	?	?	Ointment base and povidone iodine	Shorea robusta (Dipterocarpaceae)	N	L	Compound I: bioactive bergenin and compound II: triterpene ursolic acid	0.025 g of isolated compounds 1 and 2 mixed with 10 g ointment base	Wounds and burn healing	6 cm	3/3 days	Two-day interval/(wound area on day 0 × wound area on day n)/wound area on day 0 × 100	?
Melo et al., 2011 [41]	Brazil	Swiss mice	30	♀	12 wk	45.0 ± 2.0 g	4	?	1	NaCl	Cratylia mollis (Leguminoceae)	N	S	Cramoll 1,4 lectin	100 g/mL	?	0.5 cm	2, 7, and 12 days	A = π × R × r	12 days
Pieters et al., 1995 [20]	Belgium	Wistar rats	40	♀	?	250–300 g	20	2	1	Not treated	Croton spp. (Euphorbiaceae)	E	Lx	3′,4-0-Dimethylcedrusin, taspine hydrochloride	0,5 mL/2x day	Wound healing activities	3 cm	Daily	?	18 days
Ahamed et al., 2008 [42]	India	Wistar rats	24	♂♀	?	240–250 g	4	6	6	Tween 80	Grewia tiliaefolia (Tiliaceae)	N	Sb	Gulonic acid γ-lactone (GAGL)	50 mg/1x day	Burns, skin diseases, inflammation, diarrhea and pruritus, chronic wounds, and gastric ulcers	?	4/4 days	?	16 days
Zyuz'kov et al., 2012 [43]	Russian	?/mice	136	♂	2 mo	22–24 g	6	?	?	Water	Aconitum baikalensis (Ranunculaceae)	?	?	Songorine, napelline, hypaconitine, 12-epinapelline N-oxide, and mesaconitine	30 mL	?	10 × 10 mm	Daily	?	16 days
Singh et al., 2005 [44]	India	Wistar rats	20	♂♀	?	150–200 g	5	6	?	Tragacanth	Elephantopus scaber (Asteraceae)	N	L	Deoxyelephantopin	50 mg	Dysuria, diarrhea, dysentery, stomach pain; eczema and ulcers, and wound healing	500 mm2	4/4 days	?	14 days
Sharath et al., 2010 [45]	India	Wistar rats	?	♂♀	?	200–250 g	2	5	?	Nitrofurazone	Bacopa monnieri (Scrophulariaceae)	N	?	Bacoside-A	200 mg	Laxative, ulcers, anemia, leucoderma, and scabies	500 mm2	4/4 days	?	16 days
Vidya et al., 2012 [46]	India	Wistar rats	30	?	?	160–200 g	4	6	?	Nitrofurazone	Entada pursaetha (Mimosaceae)	N	S	Entadamide, phaseoloidin, and entagenic acid	?	Cancer, dropsy, eye diseases, wounds, snake bite, respiratory problems, and antibacterial	500 mm2	4/4 days	?	16 days

Ad: adults; wk: week; mo: month; d: days; ♂: male; ♀: female; N: native; E: exotic; L: leaves; F: flowers; Sb: stem bark; S: seed; Wp: whole plant; Fr: fruits; Lx: latex; ?: not related.