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Determination of glucose homeostasis with ip GTT. Basal glucose (A), GTT (B), and AUC (C) at 6, 10, and 18–20 weeks of age. For the cohort of 18- to 20-week OVX mice, both genotypes were ovariectomized at 2.5 weeks of age and remained without gonadal sex steroids for the rest of the study; n = 8–13 per group; *, P < .05; **, P < .01; ***, P < .001.
