Table 1.
Metabolic and BW Parameters in Kiss1r KO Females at Different Ages or in Adult OVX Mice
| Phenotypic Parameter | 6 Weeks | 10 Weeks | 18–20 Weeks | 18–20 Weeks (OVX) |
|---|---|---|---|---|
| Increased BW | No | √ (10%) | √ (32%) | √ (22%) |
| Increased adiposity | √ (35%) | √ (60%) | √ (125%) | √ (100%) |
| Increased leptin | √ (80%) | √ (140%) | √ (300%) | √ (65%) |
| Decreased VO2 | √ (20%) | √ (22%) | √ (28%) | √ (22%) |
| Decreased CO2 | √ (20%) | √ (22%) | √ (30%) | √ (25%) |
| Decreased energy expenditure | √ (15%) | √ (15%) | √ (20%) | √ (15%) |
| Decreased food intake | No | No | √ (35%) | √ (25%) |
| Decreased water intake | No | No | √ (45%) | √ (25%) |
| Glucose intolerance (increased AUC) | No | √ (18%) | √ (32%) | √ (25%) |
“No” indicates that there was no significant difference in this measure between control and KO females at this age; a check mark indicates that this measure was significantly different from controls. Percentage values in parentheses indicate approximate % increase or % decrease relative to control females at same age. Percentage values for adult OVX KOs are in comparison with adult OVX control mice similarly ovariectomized at 2.5 weeks of age. Food intake, water intake, VO2, VCO2, and energy expenditure values are for the dark period of the light-dark cycle, when mice are most active. Note that food and water intake at 10 weeks were both normal in the dark cycle although moderately reduced in the light portion.