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. 2016 Sep 30;157(11):4094–4103. doi: 10.1210/en.2016-1583

Figure 5.

Figure 5.

Disturbances in global glucose metabolism in ΔGlut4 mice. A, Body weight of male control and ΔGlut4 mice (n = 8–11 mice). B, Fat pad mass at 12 weeks of age (n = 12–17 mice). Fat pad mass is normalized to body mass. C, Food intake measured in the CLAMS system (n = 8–9 mice). D, Ambulatory activity measured by beam breaks in the CLAMS system (n = 8–9 mice). E, Random-fed and fasting blood glucose levels in control and ΔGlut4 mice (n = 6–10 mice). F, Serum insulin levels in control and ΔGlut4 mice (n = 5 mice). G, Glucose tolerance testing was performed at 12 weeks of age after fasting overnight (n = 8–10 mice). H, Insulin tolerance testing (ITT) was performed after fasting for 4 hours (n = 6–8 mice). I, Area under the curve analysis for GTT and ITT studies. J, Representative insulin-stained β-cell islets from 12-week-old control (top) and ΔGlut4 (bottom) mice and quantitation of islet area (n = 6 mice). Glucose infusion rate (K) was assessed during euglycemic hyperinsulinemic clamps. L, qPCR analysis of Acadm mRNA levels in the skeletal muscle of 12-week-old control and ΔGlut4 mice (n = 5 mice). M, qPCR analysis of Pparγ2 mRNA levels in the gonadal fat pad of 12-week-old control and ΔGlut4 mice (n = 5 mice).