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. 2016 Sep 21;157(11):4133–4145. doi: 10.1210/en.2016-1678

Figure 2.

Figure 2.

The rs2232316 G6PC2 SNP has opposite effects on basal and Dex-stimulated promoter activity. A–D, The influence of the alternate alleles of the rs573225 and rs2232316 SNPs on basal (A and C) and Dex-stimulated (B and D) G6PC2-luciferase fusion gene expression was analyzed by transient transfection in βTC-3 cells. The rs573225-G and rs2232316-A alleles both increase basal expression but only the rs2232316-A allele affects the Dex response. Results show the mean ± SEM of 3 experiments; *, P < .05 vs control. E, Effect of Foxa2 overexpression on Dex-stimulated G6PC2-luciferase fusion gene expression in 832/13 cells. Overexpression of Foxa2 inhibits G6PC2-luciferase fusion gene expression. Results show the mean data ± SD; *, P < .05 vs control.