Table 1.
Current FDA-approved therapies for melanoma.
| Type of therapy | Drug name | Mechanism of action |
|---|---|---|
| Immunotherapy | Interferon alfa-2b | IFNAR/JAK/STAT activation |
| Interleukin-2 | Immune cell activation | |
| Ipilimumab | Anti-CTLA-4 monoclonal antibody | |
| Nivolumab | Anti-PD-1 monoclonal antibody | |
| Pembrolizumab | Anti-PD-1 monoclonal antibody | |
| Talimogene laherparepvec | Oncolytic viral therapy | |
| Targeted therapies | Cobimetinib | MEK inhibitor |
| Dabrafenib | BRAFV600E inhibitor | |
| Trametinib | MEK-1/2 inhibitor | |
| Vemurafenib | BRAFV600E inhibitor | |
| Chemotherapy | Dacarbazine | DNA alkylating |
| Temozolomide | DNA alkylating/methylating |
List of types of the therapy and specific drugs with corresponding mechanisms of action, currently in use for melanoma treatment.