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Formation of the palm:connection interface in p66E. (A) β-sheet structure formed from palm loop residues (gold) and following palm domain residues 231–241 (blue), and residues 313–317 in the connection domain (magenta), that form the new palm:connection interface; (B) Formation of the β-sheet also creates a binding pocket for connection domain residue Tyr318, which also forms an H-bond with His235.
