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. 2016 Sep 27;8(10):260. doi: 10.3390/v8100260

Figure 8.

Figure 8

Formation of the connection:RH interface. (A) Superposition of the connection:RH interface region of the p66 subunit of the RT heterodimer (color coded as in Figure 2) with the monomer connection domain (gray). Formation of the connection:RH interface requires straightening of helix αL, which also requires movement of the αL–β21 loop. These adjustments are required to form both the intra-subunit connection:RH interface and the inter-subunit connection:connection’ interface. Trp406 moves approximately 13 Å to make contact with the RH domain (the α-carbon displacement is 11 Å); (B) Rotated view illustrating movement of the β18–αK loop and conformational changes at the connection:RH interface that result in several of the observed RH domain Ile shifts previously reported [24]. Black hyphenated lines indicate the altered helix structure, and green arrows indicate conformational changes.