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. 2016 Oct 22;8(10):292. doi: 10.3390/v8100292

Figure 1.

Figure 1

Human PyV particles are composed of 72 pentamers of the capsid protein VP1, with one of the minor capsid proteins VP2 or VP3 in the center of each pentamer. The human PyV genome is divided into three regions: a non-coding region, containing the early and late promoters, transcription sites and the origin of replication; an early region encoding small T antigens (sT), large T antigens (LT) and alternatively-spliced LT antigens (LT’); and a late region encoding the viral structural proteins VP1, VP2 and VP3. Among human polyomaviruses, only BKPyV and JCPyV encode an agnoprotein (agno) upstream of VP1. Merkel cell PyV (MCPyV) does not encode the minor capsid protein VP3.