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Overview of immunotoxin design. (A) Representation of anti-GPC3 antibodies and their approximate binding sites. YP7 and HN3 bind to the core protein near the C-terminus and a conformational epitope that requires both the N-terminus and the C-terminus, respectively. HS20 binds directly to the heparan sulfate chains associated with GPC3; (B) Construction of HN3-PE38 and the second generation HN3-mPE24; (C) HN3 immunotoxin domains and their associated functions.
