Table 11.
Down-regulation of CXCR4, CXCL12, p52, p65, p70S6K and p100 by C. speciosus active ingredients.
| Mechanism | Ingredients | Cell | References |
|---|---|---|---|
| Down-regulation of C-X-C chemokine receptor type 4 (CXCR-4) | Zerumbone | Breast cancer (HER2) | [110] |
| Chronic Myelogenous Leukemia (KBM-5) | |||
| Human myeloma (U266) | |||
| Human squamous carcinoma (SCC4) | |||
| Human embryonic kidney (A293) | |||
| Human non-small cell lung carcinoma (H1299) | |||
| Human pancreatic carcinoma (PANC-1) | |||
| Pancreatic carcinoma (PANC-28) | |||
| Human pancreatic carcinoma (MIA PaCa-2) | |||
| Down-regulation of C-X-C motif chemokine 12 (CXCL12) | Zerumbone | Breast cancer (HER2) | [110] |
| Human pancreatic carcinoma (PANC-1) | |||
| Pancreatic carcinoma (PANC-28) | |||
| Human pancreatic carcinoma (MIA PaCa-2) | |||
| Down-regulation of p38 | Diosgenin | Human esophageal cancer (Eca109) | [117] |
| Human erythroleukemia (HEL) | [44] | ||
| Down-regulation of p52 | Costunolide | Breast cancer (MDA-MB-231) | [107] |
| Down-regulation of p65 | Costunolide | Breast cancer (MDA-MB-231) | |
| Down-regulation of p70S6K | Lupeol | human osteosarcoma cells (MG-63) | [31] |
| human pancreatic cancer (PCNA-1) | [32] | ||
| Down-regulation of p100 | Costunolide | Breast cancer (MDA-MB-231) | [107] |