Table 3.
Up-regulation of Bax by C. speciosus active ingredients.
| Mechanism | Ingredients | Cell | References |
|---|---|---|---|
| Up-regulation of Bax | Costunolide | Human bladder carcinoma (T24) | [6] |
| Diosgenin | Human erythromyeloblastoid leukemia (K562) | [29] | |
| Human erythroleukemia (HEL) | [57] | ||
| Human lung carcinoma (A549) | [40] | ||
| Human epidermoid carcinoma (A431) | [43] | ||
| Human hepatocellular carcinoma (Hep2) | |||
| Human erythroleukemia (HEL) | [41] | ||
| Lupeol | Human epidermoid carcinoma (A431) | [58] | |
| Melanoma (451Lu) | [33] | ||
| Head and neck squamous cell carcinoma (HNSCC) | [46] | ||
| Zerumbone | Human lung cancer (NSCLC) | [24] | |
| Human hepatocellular carcinoma (HepG2) | [59] | ||
| Intracellular Ca2+ increase | Camphene | Murine melanoma cell (B16F10-Nex2) | [34] |
| Zerumbone | Human prostate cancer (PC-3) | [60] | |
| Human prostate cancer (DU-145) | |||
| Chronic myeloid leukemia (CML) | [49] | ||
| Human erythromyeloblastoid leukemia (K562) | |||
| Overload of nuclear Ca2+ | Costunolide | Human prostate cancer (PC-3) | [26] |
| Human prostate cancer (DU-145) | |||
| Human prostate adenocarcinoma (LNCaP) |