Table 5.
Up-regulation of some apoptotic molecules by C. speciosus active ingredients.
| Mechanism | Ingredients | Cell | References |
|---|---|---|---|
| Up-regulation of Apaf1 | Lupeol | Human epidermoid carcinoma (A431) | [58] |
| Up-regulation of AIF | Diosgenin | Human osteosarcoma (1547) | [21] |
| Cervix carcinoma (HEp-2) | |||
| Human melanoma (M4Beu) | |||
| Up-regulation of ATF3 | Zerumbone | Human colon carcinoma (HCT116) | [67] |
| Human colon adenocarcinoma (SW-480) | |||
| Up-regulation of E-cadherin | Diosgenin | Human gastric cancer (BGC-823) | [68] |
| Up-regulation of FADD | Lupeol | Human hepatoma cells (SMMC-7721) | [69] |
| Up-regulation of Fas | Costunolide | Breast cancer (MDA-MB-231) | [27] |
| Zerumbone | Acute promyelocytic leukemia (NB4) | [48] | |
| Up-regulation of integrin α5 | Diosgenin | Human gastric cancer (BGC-823) | [68] |
| Up-regulation of integrin β6. | Diosgenin | Human gastric cancer (BGC-823) | [68] |
| Up-regulation of Notch2 | Zerumbone | Human breast adenocarcinoma (MCF-7) | [70] |
| Breast cancer (MDA-MB-231) | [70] | ||
| Up-regulation of PTEN | Lupeol | Hepatocellular carcinoma (MHCC-LM3 HCC) |
[71] |
| Up-regulation of Rab27a | Lupeol | Mouse melanoma (B16 2F2) | [72] |
| Up-regulation of thromboxane synthase | Diosgenin | Human erythroleukemia (HEL) | [41] |
| Up-regulation of DR4 | Zerumbone | Human colon carcinoma (HCT116) | [64] |