Table 8.
Down-regulation of Bcl-2 and Bcl-xL by C. speciosus active ingredients.
| Mechanism | Ingredients | Cell | References |
|---|---|---|---|
| Down-regulation of Bcl-2 | Costunolide | Human bladder carcinoma (T24) | [6] |
| Human ovarian carcinoma (SKOV3) | [37] | ||
| Human ovarian carcinoma (A2780) | |||
| Human ovarian carcinoma (SKOV3) | |||
| Diosgenin | Human lung carcinoma (A549) | [40] | |
| Human epidermoid carcinoma (A431) | [43] | ||
| Human hepatocellular carcinoma (Hep2) | |||
| Human erythroleukemia (HEL) | [41] | ||
| Human breast carcinoma (BCa) | [92] | ||
| Human erythromyeloblastoid leukemia (K562) | [29] | ||
| Human colon adenocarcinoma (HT-29) | [45] | ||
| Human erythroleukemia (HEL) | [57] | ||
| Human erythromyeloblastoid leukemia (K562) | [39] | ||
| Human promyelocytic leukemia (HL-60) | |||
| Lupeol | Human epidermoid carcinoma (A431) | [58] | |
| Human breast adenocarcinoma (MCF-7) | [106] | ||
| Melanoma (451Lu) | [33] | ||
| Head and neck squamous cell carcinoma (HNSCC) | [46] | ||
| Zerumbone | Human renal carcinoma (786-0) | [51] | |
| Human renal carcinoma (769-P) | |||
| Human hepatocellular carcinoma (HepG2) | [59] | ||
| Down-regulation of Bcl-xL | Diosgenin | Human erythroleukemia (HEL) | [44] |
| Human erythromyeloblastoid leukemia (K562) | [29] | ||
| Lupeol | Human breast adenocarcinoma (MCF-7) | [106] | |
| Zerumbone | Human prostate cancer (PC-3) | [60] | |
| Human prostate cancer (DU-145) | |||
| Human colon carcinoma (HCT116) | [93] |