Table 9.
Down-regulation of NF-κB, JAKs and JNK by C. speciosus active ingredients.
| Mechanism | Ingredients | Cell | References |
|---|---|---|---|
| Down-regulation of NF-κB | Costunolide | Breast cancer (MDA-MB-231) | [107] |
| Diosgenin | Human prostate cancer (PC-3) | [87] | |
| Human erythroleukemia (HEL) | [44] | ||
| Human breast carcinoma (BCa) | [92] | ||
| Lupeol | Head and neck squamous cell carcinoma (HNSCC) | [46] | |
| human pancreatic adenocarcinoma cells (AsPC-1) | [108] | ||
| Zerumbone | Pancreatic cancer (PaCa) | [109] | |
| Breast cancer (HER2) | [110] | ||
| Breast cancer (MDA-MB-231) | [111] | ||
| Human gastric carcinoma (AGS) | [112] | ||
| Down-regulation of JAK1 | Diosgenin | hepatocellular carcinoma (HCC) | [113] |
| Down-regulation of JAK2 | Diosgenin | hepatocellular carcinoma (HCC) | [113] |
| Zerumbone | Human prostate cancer (DU145) | [101] | |
| Human prostate cancer (PC-3) | |||
| Down-regulation of JAKs | Lupeol | Human hepatocellular carcinoma (HepG2) | [56] |
| Human liver hepatoma (PLC/PRF5) | |||
| Human hepatoma-derived (C3A) | |||
| Hepatocarcinoma (HUH-7) | |||
| Human hepatoma (Hep3B) | |||
| Down-regulation of JNK | Diosgenin | Breast cancer (HER2) | [91] |
| Human prostate cancer (PC-3) | [87] | ||
| Human epidermoid carcinoma (A431) | [43] | ||
| Human hepatocellular carcinoma (Hep2) |