Table 7.
Interaction of five SNPs and environmental risk factors on lung cancer risk.
| Cooking Oil Fume Exposure | Genotype | Cases (%) | Controls (%) | Adjusted OR a | 95% CI | p Value | Passive Smoking Exposure | Cases (%) | Controls (%) | Adjusted OR a | 95% CI | p Value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs7813 | ||||||||||||
| − | CT + CC | 68 (30.4) | 118 (48.4) | Ref | − | 46 (20.5) | 62 (25.4) | Ref | ||||
| − | TT | 74 (33.0) | 74 (30.3) | 1.836 | 1.073, 3.143 | 0.027 * | − | 47 (21.0) | 54 (22.1) | 1.189 | 0.613, 2.305 | 0.609 |
| + | CT + CC | 46 (20.5) | 36 (14.8) | 2.266 | 1.182, 4.343 | 0.014 * | + | 68 (30.4) | 92 (37.7) | 1.022 | 0.564, 1.851 | 0.940 |
| + | TT | 36 (16.1) | 16 (6.6) | 1.778 | 0.688, 4.598 | 0.235 | + | 63 (28.1) | 36 (14.8) | 2.578 | 1.266, 5.252 | 0.009 * |
| rs2740349 | ||||||||||||
| − | AG + GG | 26 (11.6) | 50 (20.5) | Ref | − | 19 (8.5) | 34 (13.9) | Ref | ||||
| − | AA | 116 (51.8) | 142 (58.2) | 1.746 | 0.920, 3.313 | 0.088 | − | 74 (33.0) | 82 (33.6) | 1.586 | 0.739, 3.402 | 0.237 |
| + | AG + GG | 18 (8.0) | 14 (5.7) | 2.384 | 0.834, 6.808 | 0.105 | + | 25 (11.2) | 30 (12.3) | 1.493 | 0.596, 3.741 | 0.392 |
| + | AA | 64 (28.6) | 38 (15.6) | 1.316 | 0.472, 3.669 | 0.600 | + | 106 (47.3) | 98 (40.2) | 2.065 | 0.974, 4.379 | 0.059 |
| rs2291778 | ||||||||||||
| − | GG | 64 (28.6) | 84 (34.4) | Ref | − | 45 (20.1) | 54 (22.1) | Ref | ||||
| − | GT + TT | 78 (34.8) | 108 (44.3) | 0.992 | 0.583, 1.685 | 0.975 | − | 48 (21.4) | 62 (25.4) | 0.903 | 0.465, 1.752 | 0.762 |
| + | GG | 40 (17.9) | 26 (10.7) | 2.028 | 0.969, 4.245 | 0.061 | + | 59 (26.3) | 56 (23.0) | 1.263 | 0.655, 2.437 | 0.486 |
| + | GT + TT | 42 (18.8) | 26 (10.7) | 2.157 | 1.031, 4.512 | 0.041 * | + | 72 (32.1) | 72 (29.5) | 1.325 | 0.700, 2.511 | 0.388 |
| rs910924 | ||||||||||||
| − | CT + TT | 32 (14.3) | 56 (23.0) | Ref | − | 20 (8.9) | 30 (12.3) | Ref | ||||
| − | CC | 110 (49.1) | 136 (55.7) | 1.437 | 0.788, 2.623 | 0.237 | − | 73 (32.6) | 86 (35.2) | 1.296 | 0.597, 2.814 | 0.512 |
| + | CT + TT | 19 (8.5) | 18 (7.4) | 1.860 | 0.721, 4.799 | 0.199 | + | 31 (13.8) | 44 (18.0) | 1.126 | 0.468, 2.707 | 0.792 |
| + | CC | 63 (28.1) | 34 (13.9) | 1.755 | 0.674, 4.572 | 0.249 | + | 100 (44.6) | 84 (34.4) | 1.863 | 0.864, 4.016 | 0.112 |
| Rs595961 | ||||||||||||
| − | GG | 93 (41.5) | 144 (59.0) | Ref | − | 56 (25.0) | 84 (34.4) | Ref | ||||
| − | AG + AA | 49 (21.9) | 48 (19.7) | 1.594 | 0.982, 2.587 | 0.059 | − | 37 (16.5) | 32 (13.1) | 0.978 | 0.955, 1.002 | 0.072 |
| + | GG | 50 (22.3) | 44 (18.0) | 1.726 | 1.060, 2.810 | 0.028 * | + | 87 (38.8) | 104 (42.6) | 1.333 | 0.850, 2.091 | 0.210 |
| + | AG + AA | 32 (14.3) | 8 (3.3) | 6.314 | 2.752, 14.485 | <0.001 * | + | 44(19.6) | 24 (9.8) | 3.139 | 1.678, 5.871 | <0.001 * |
a Adjusted for age, ORs and 95% CIs were calculated by logistic regression; * p < 0.05. Bold values indicate significance after Bonferroni correction (k = 6).