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. 2016 Oct 31;3(5):ENEURO.0230-16.2016. doi: 10.1523/ENEURO.0230-16.2016

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Copyright © 2016 Zhang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 7. — Conditional deletion of both Lhx2 and Emx2 in immature OSNs reduces OR expression frequencies. A, In situ hybridization shows that Olfr308 is expressed in scattered OSNs in the ventral olfactory epithelium. B, In 123Cre:Lhx2^fl/fl:Emx2^fl/fl mice, the frequency of OSNs expressing Olfr308 appears to be reduced. NC, Air space of the nasal cavity; S, nasal septum; T, turbinate. Scale bars, 100 µm. C, Normalized cell counts from in situ hybridization images show that ORs are less frequently expressed in 123Cre:Lhx2^fl/fl:Emx2^fl/fl mice compared with littermate controls. Diff., Normalized fold differences from the microarray experiment. *Significant difference (p 0.01; n 4; FDR 1%).