Figure 4.

Effect of IKKβ knockdown in NAc on ethanol (EtOH) intake and preference during the 24 h two-bottle choice test in Ikkb^F/F mice. A, Ethanol consumption (g/kg/24 h). B, Preference for ethanol. C, Total fluid intake (g/kg/24 h). Each point is the average of 2 d of drinking ± SEM. Significant main effect of treatment is shown by the p value (two-way ANOVA with repeated measures). Significant post hoc effect of LV-EGFP-Cre compared with LV-EGFP-Empty treatment is indicated by symbols above each time point (Bonferroni test for multiple comparisons *p < 0.05, **p < 0.01). n = 32 animals injected with LV-Cre-EGFP; n = 20 injected with LV-Cre-Empty.