Table 3.
Statistically significant (p<0.05) interactionsa between antioxidant & vitamin E transport SNPs and vitamin E supplementation interactions (p < 0.05) for risk of high-grade prostate cancer (N=1,124)
| Genotype frequency | Hazard ratio (95% CI) high- grade cancer |
|||||
|---|---|---|---|---|---|---|
| Gene | Genotype | N (%) cases | N (%) controls |
Placebo arm | Vitamin E arm | p-valueb |
| SEC14L2 | rs5753106 | |||||
| AA | 106 (59.2%) | 543 (57.6%) | 1.0 | 0.98 (0.64,1.49) | 0.008 | |
| AG | 65 (36.3%) | 347 (36.8%) | 0.74 (0.44,1.24) | 1.25 (0.80,1.97) | ||
| GG | 8 (4.5%) | 52 (5.5%) | 0.14 (0.02,0.99) | 1.57 (0.63,3.91) | ||
| TTPA | rs12679996 | |||||
| CC | 69 (38.5%) | 361 (38.9%) | 1.0 | 2.29 (1.32,3.97) | 0.001 | |
| CT | 77 (43.0%) | 426 (46.0%) | 1.34 (0.74,2.40) | 1.70 (0.98,2.94) | ||
| TT rs4606052 | 33 (18.4%) | 140 (15.1%) | 2.76 (1.44,5.29) | 1.33 (0.60,2.97) | ||
| CC | 62 (35.4%) | 271 (29.9%) | 1.0 | 2.25 (1.26,4.03) | 0.007 | |
| CT | 68 (38.9%) | 434 (48.0%) | 0.97 (0.53,1.79) | 1.27 (0.71,2.25) | ||
| TT | 45 (25.7%) | 200 (22.1%) | 2.02 (1.06,3.82) | 1.38 (0.69,2.75) | ||
a
Full results for all analyzed SNP x vitamin E assignment interactions are presented in Supplementary Table 3
b
P-value for test for interaction between SNP and selenium assignment for the outcome of risk of high-grade prostate cancer