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. 2016 Oct 31;6:36064. doi: 10.1038/srep36064

Figure 7. Immunization with the MOG196-pulsed DCs activates CD8+ T cells that transfer EAE suppression.

Figure 7

(A) C57BL/6 mice intravenously received no immunization (none-immune), DCs (DC), or MOG196-pulsed DCs (MOG196-DC). Twenty days later, CD8+ T cells from the animals in each group were purified and pooled. Host animals were divided into the following groups: no treatment; DC/CD8 in which each animal received 1 × 106 CD8+ T cells from the animals immunized with the DCs; MOG196-DC/CD8 in which each animal received 1 × 106 CD8+ T cells from the animals immunized with the MOG196-pulsed DCs; or none-immune/CD8 in which each animal received 1 × 106 CD8+ T cells from the none-immunized animals. On the second day, all animals were immunized with the MOG35-55 for inducing EAE and monitored for paralytic symptoms daily. (B) Cumulative data of mean disease scores from five animals in each group. *P < 0.05 No Tx vs. MOG196-DC/CD8. Mann Whitney test.