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. 2016 Oct 31;6:36170. doi: 10.1038/srep36170

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Molecular modeling of Hsp90 protein with compound 1 as assessed by Autodock 4.2 software with Lamarckian Genetic Algorithm. (17-AAG: labeled with yellow; Compound 1: labeled with purple). (B) Effect of 17-AAG on cytotoxicity of Molt 4 cells. (C) Effect of compound 1 on expression of Hsp90 client proteins. (D) Effect of compound 1 on localization of Hsp70 protein.